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KMID : 0358619930270010051
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Korean Journal of Physiology
1993 Volume.27 No. 1 p.51 ~ p.55
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Both Nifedipine and Bay K 8644 Potentiate the Release of Atrial Natriuretic Peptide in Response to Volume Expansion
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Lee Jong-Un
Koh Cheon-Suk
Yeum Cheol-Ho
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Abstract
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The effects of a calcium channel blocker and an activator on the release of atrial natriuretic peptide (ANP) were investigated in rats. They were volume expanded (VE) up to 5% of the body weight over 30min by being infused with iso-oncotic saline. Following VE, plasma ANP concentration markedly increased in association with increases in the right atrial pressure. Addition of either nifedipine () or Bay K 8644 () in the infusate potentiated the VE-induced release, although neither of them affected the right atrial pressure. The nifedipine added group showed a lower mean arterial pressure than the Bay K added group throughout the infusion period. VE decreased plasma renin concentration, the magnitude of which was attenuated by nifedipine but not by Bay K. It may be hypothesized that a decrease in cytoplasmic calcium is primary stimulus far the ANP release, and an increase plays o role in secondary liberation of the ANP accumulated in the interstitium into the lumen of the atria through myocardial contraction. further studies will be needed to confirm the hypothesis.
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KEYWORD
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Atrial natriuretic peptide, Volume expansion, Calcium, Nifedipine, Bay K 8644, Renin
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